Power of OneArray™ - Annotation
| Phalanx Biotech Whole Genome Annotation Pipeline |
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| In an effort to investigate how to generate a more complete probe set, a probe annotation pipeline has been developed using the whole genome as a reference set. Analysis of available human gene expression microarrays indicates increased probe density does not correlate with increased gene coverage or interrogation power. |
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Figure 1: Overview of the annotation pipeline. |
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| OneArray™ Interrogation Power |
 Figure 2: Probe Set Breakdown  Figure 3: Interrogation Power |
The annotation pipeline was used to evaluate probe sets from several different sources. Probes were assigned to six different categories based on their alignment to the whole genome. |
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 Table 1: Annotation criteria |
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The break down for the probe sets investigated (Figure 2) indicates sets with high probe density have a large amount of probe space dedicated to intergenic material (orange). |
