Research Highlights

Date Focus Summary
02/01/17
Cancer Genomics (HmiOA) This month's featured article is from the lab of Xiaoxiang Guan of Nanjing University in Nanjing, China. The article was published in the journal Molecular Medicine Reports and focuses on whether miRNAs have an effect on androgen receptor expression during breast cancer.
12/01/16
Cell Death Genomics (HOA) This month's featured article is from the labs of Z-B Jin and F Lu of the Lab for Stem Cells and Retinal Regeneration at Wenzhou Medical University in Wenzhou, China. The article was published in the journal Cell Death Discovery and investigates the mechanisms of light-induced apoptosis in retinal pigmented epithelial cells.
11/05/16
Cardiovascular Genomics (MOA) This month's featured article is from the labs of Robert Schwartz and Bradley McConnell of the University of Houston in Texas. The article was published in the journal Scientific Reports and characterizes Mesp1-expressing cardiac progenitor cells and their role in treating injured hearts.
09/12/16
miRNAs & Development (MOA) This month's featured article is from the labs of Robert Schwartz and Yu Liu of the University of Houston in Texas. The article was published in the journal PNAS and investigates how miR-503 and miR-322 regulate cardiac progenitor cell fate.
08/12/16
Cell Biology (HOA) This month's featured article is from the labs of Hong-tao Wang and Da-hai Hu of Fourth Military Medical University in Xi'an, China. The article was published in the journal Scientific Reports and investigates how miR-146a mediates angiogenesis in human umbilical vain endothelial cells.
07/13/16
Cancer Genomics (HOA) This month's featured article is from John T-A Hsu of National Chiao Tung University in Hsinchu, Taiwan. The article was published in the journal OncoTargets and Therapy and investigates how non-small cell lung cancers develop resistance to targeted therapeutics.
06/25/16
Cancer Genomics (HOA) This month's featured article is from the lab of Yide Qin of Anhui Medical University in Hefei, China. The article was published in the journal BMC Cancer and focused on the mechanism of activity of a milk-derived anti-cancer fusion peptide in ovarian cancer.
05/12/16
Molecular Diagnostics (HOA) This month's featured article is from Julia Tzu-Ya Weng of Yuan Ze University in Taoyuan, Taiwan. The article was published in the journal BMC Bioinformatics and focused on the identification of diagnostic biomarkers for latent and active tuberculosis infection.
03/30/16
Cancer Genomics (HOA) Our next featured article is from Pei-Ming Yang of Mackay Memorial Hospital in Taiwan. The article was published in the journal Oncoscience and focused on the treatment of hepatocellular carcinoma with a small molecular inhibitor targeting the EZH2 protein.
03/03/16
Toxicogenomics (MOA) This month's featured article is from Hong Chen of Northwest A&F University in China. The article was published in the journal PLoS One and focused on the inhibition of ovarian follicle growth by DEHP, a plastic additive and environmental health hazard.
02/08/16
Cancer Genomics (HOA) This month's featured article is from Eing-Mei Tsai of Kaohsiung Medical University in Taiwan. The article was published in the journal Scientific Reports and focused on the suppression of breast cancer growth by a synthetic peptide that inhibits the interaction between Beta-catenin and LEF-1.
01/04/16
Cardiovascular Genomics (MOA) This month's featured article is from James Martin of the Texas Heart Institute and Baylor College of Medicine in Houston, Texas. The article was published in the journal Science Signaling and focused on pathways underlying heart regeneration.
12/08/15
Physiological Genomics (MRmiOA) This month's featured article is from Ching-Hua Hsieh of the Department of Plastic and Reconstructive Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taiwan. The article was published in the journal BMC Genomics and focused on circulating miRNAs underlying diet-induced obesity.
11/23/15
Physiological Genomics (MOA) Our next featured article is from Maija Mednieks and Art Hand of the University of Connecticut. The article was published in the journal Gravitational and Space Research and focused on how space flight affects salivary gland gene expression.
11/03/15
Respiratory Genomics (MOA) This month's featured article is from Qiang Li of Shanghai Jiaotong University School of Medicine in China. The article was published in the journal Scientific Reports and focused on the role of Nogo-B in protecting lung tissue from LPS-induced injury.
10/20/15
Physiological Genomics (Agilent Service) This month's featured article is from Gene Ables of the Orentreich Foundation for the Advancement of Science. The article was published in the journal Scientific Reports. The study focused on cardiac physiology underlying life span extension in methionine-restricted mice.
09/14/15
Cancer Genomics (HOA) This month's featured article is from Einav Shoshan of University of Texas MD Anderson Cancer Center. The article was published in the journal Nature Cell Biology. The study focused on RNA editing of miR-455-5p by ADAR1 and its role in melanoma growth and metastasis.
08/05/15
Cancer Genomics (HmiOA) This month's featured article is from Natarajan Aravindan of University of Oklahoma Health Science Center in Oklahoma City. The article was published in the journal BMC Genomics. The study characterized many miRNAs underlying the metastasis of neuroblastoma, or so called metastamiRs.
07/01/15
Traditional Chinese Medicine (HOA) This month's featured article is from Maria Lambros of Western University of Health Sciences in Pomona, CA. The article was published in the journal Evidence-Based Complementary and Alternative Medicine. The study found that Qingre Liyan decoction and N-Acetyl Cysteine prevent radiation-induced mucositis via regulation of the Nrf2 pathway.
06/01/15
Developmental Biology (MOA) This month's featured article is from researchers at the Univ of Houston and the Univ of Texas, Austin. The article was published in the journal PLoS One. The study found that the gene Smyd1 is critical to heart formation via regulation of oxidative and ER stress responses.
05/02/15
Cancer Genomics (HOA) This month's featured article is from researchers at Thomas Jefferson University in Philadelphia. The article was published in the journal Cancer Research. The study found that the gene Dachshund (DACH1) is a regulator of tumor growth in the prostate via control of cytokine secretion.
03/25/15
miRNAs and Cell Death (HmiOA) This month's featured article is from Professor Tan of Southern Medical University in China. The article was published in the journal Cell Death & Disease. The study found that by targeting Akt3, miR-207 enhances IR-induced apoptosis and anti-miR-207 may potentially play a role in protecting HEI-OC1 cells from IR.
11/19/14
Traditional Chinese Medicine (MOA) This month's featured article is from Hsin-Yi Lo of China Medical University in Taiwan. The article was published in the journal PLOS ONE. The study found that CYSKT affected insulin signaling pathway, decreased HbA1c and blood glucose levels, and reduced mortality rate in type 2 diabetic mice.
10/20/14
Cancer Genomics (HmiOA) This month's featured article is from Zhiguo Liu of Shandong University in China. The article was published in the online journal Tumor Biology. The study found that MiR-7-5p targets RAF1 to inhibit vascular endothelial cell proliferation.
09/29/14
Plant Genomics (RiOA) This month's featured article is from Ching-Hui Yeh of National Central University in Taiwan. The article was published in the journal Plant Molecular Biology. The study characterizes a new RING zinc-finger protein in the rice genome, OsRZFP34, which functions in stomata opening.
08/12/14
Cancer Genomics (HOA+HmiOA) This month's featured article is from Peter Ruvolo of MD Anderson Cancer Center. The article was published in the journal Biochimica et Biophysica Acta. The study focuses on protein phosphatase 2A regulatory subunit B55α and its role in acute myeloid leukemia.
07/01/14
Cancer Genomics (HOA) This month's featured article is from Huazhong University of Science and Technology, China. The article was published online April 15th, 2014 in the journal Leukemia. The study focuses on the Piwi-interacting RNA, piRNA-823, and its role in the epigenetic regulation of multiple myeloma.
06/11/14
Cancer Genomics (HOA) This month's featured article is from National Taiwan University. The article was published online March 31st, 2014 in the journal Oncogene. The study focuses on the mechanisms by which BCL10 protein promotes oral cancer progression.
05/20/14
Stem Cell Biology (HmiOA) This month's featured article is from Academia Sinica and other institutions in Taiwan. The article was published in the March 2014 edition of Nature Cell Biology. The study focuses on the mechanisms by which deregulation of asymmetric cell division drives tumor growth in colorectal cancer stem cells.
04/16/14
Yeast/Plant Genomics (YOA) This month's featured article is from the lab of Dr. Leon Kochian at the USDA Agricultural Research Service and Cornell University. The article was published in the March 2014 edition of the Journal of Integrative Plant Biology. The study focuses on the evolutionary conservation of Zn homeostasis regulation in plants and yeast.
03/04/14
Toxicogenomics (HOA) This month's featured article is from the lab of Dr. David Fucht at the U.S. Food and Drug Administration. The article was published in the February 14th edition of Journal of Biological Chemistry. The study focuses on the mechanism by which hypoxia contributes to the pathology of anthrax lethal toxin.
01/28/14
Cancer Genomics (MOA) This month's featured article is from the labs of Professor Zihai Li at University of Connecticut Health Center and Professor Bei Lu at Medical University of South Carolina. The article was published in the January 15th edition of Cancer Research. The study focused on the mechanisms by which macrophages drive the development of inflammation-associated colon cancers.
12/24/13
Cancer Genomics (HOA) This month's featured article is from the lab of Professor Wang Hongyang of Shanghai Jiaotong University. Professor Wang's research team recently published their results in the journal Cell Death and Disease. The study focused on the mechanisms by which compound C, a well-known inhibitor of AMPK, induces apoptosis.
11/26/13
Tissue Regeneration (HOA) This month's featured article is from the lab of Professor Tanja Dominko at Worchester Polytechnic Institute in Massachusetts. The article was published on September 26th in the journal BMC Genomics. The study focuses on the balance between regeneration and scar formation following skeletal muscle injury.